Some do but as with RSI from keyboard/mouse usage it affects everyone differently. One thing they usually have in common is excessive repetition for example by constantly using shortcuts with CTRL. While practicing typing (both keyboard and gamepad) I noticed that highly repetitive lessons with lots of text like "jf jf jf fj fj fj jfjfjfj" cause much more strain than lessons with more realistic text. In the end it all comes down to responsible usage, nothing is completely safe.