Every sane large internal network is segmented. I doubt all the "more than 16 million devices" need to talk to every other device. The IPv4 limit is an annoyance, but not a big one for the typical internal networks.
When my internal network connects, via any non-NATed means, to a vendor’s internal network, there is a chance that my addresses conflict with theirs. If the vendors have even a few tens of clients, this risk is quite high.