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by Duller-Finite
2148 days ago
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As a follow-up for those that have said genetic studies have been fruitful, here's excerpts from the most recent genetic study [1]. This study looked at a link in the μ-opioid receptor gene, which was the only gene that barely reached genome-wide significance in their meta-analysis of 8529 individuals with opioid use disorder (OUD). In contrast, smoking, alcohol use, and education status showed clear effects on OUD. "Understanding the genetic architecture of OUD might provide clinically useful clues about its biology. However, to our knowledge, only a few risk variants have been identified by GWAS so far, and none has had clear external replication. Several factors contribute to this situation: (1) OUD is a complex psychiatric disease with relatively low heritability, and there is no single variant with a large effect size that can be detected in small cohorts" [1] https://jamanetwork.com/journals/jamapsychiatry/article-abst... |
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