[mkl]

This matches glucosamine's effect on me pretty well. I have a genetic joint condition that makes any repetitive motion cause damage and pain. Glucosamine (4500mg/day) is provably the one thing that lets me have a normal career (carefully chosen job still). If I stop taking it for a few days, that's a problem. I stepped up to that dosage, noticing clear improvements a week or so after each increase.

I couldn't run 15 miles though! Walking 1km is risky even on a good day, even with glucosamine.