[cyann]

Same here, I've got this one-liner in my system config:

Inverse or reverse mouse wheel (natural scrolling), reboot or unplug the mouse. Must be run in an admin powershell console.

Get-ItemProperty HKLM:\SYSTEM\CurrentControlSet\Enum\HID\\\Device` Parameters FlipFlopWheel -EA 0 | ForEach-Object { Set-ItemProperty $_.PSPath FlipFlopWheel 1 }

[Wowfunhappy]

I used to use this, but I found that it sometimes got disabled when I unplugged and replugged my mouse (and always if I later got a new mouse). I eventually gave up.