[bob1029]

Multiprocess can work, but you may want to develop an intermediary process that is exclusive owner of the database for performance reasons and then delegate to it. I.e. you could have:

database.db <=> SQLiteAgent <=> localhost HTTP JSON <=> MyPythonWebApps

This exercise would also encourage development of a concise and generic schema for storing your business data (presumably because changes to the above JSON contract would be time consuming).