[aroch]

Hey Stavros. We were looking for a data-store to integrate into a clinical genomics LIMS that supports in-system analysis. We deal with de novo sequenced clinical samples (and not genotyped samples, which seems to be what TileDB-vcf had in mind?). There are some edge cases that TileDB-vcf explicitly disallows (updates/reinserts to the same sample, overlapping variants) that are not edge cases for us but rather common occurrences.

[stavrospap]

This is an API issue with TileDB-VCF. The core TileDB library supports inserts/appends/overwrites without issues and we just need to expose those operations in the TileDB-VCF APIs. Added to our backlog, thanks!