[jraph]

Sure. Download the APK from the F-Droid website [1] and install it with adb install. If you want to build it yourself, you can build it like any regular Android app with gradle, or by following the F-Droid recipe [2] (edit: which does not provide much useful information in the case of NewPipe, but it can be a great source of information for apps that are more difficult to build, especially if you want to remove the proprietary bits / tracking parts).

You won't get automatic updates, though. I encourage you to install F-Droid (that you can also install using adb install), and enable third party sources just for F-Droid (which is possible on the latest versions of Android). Or, if your bootloader is unlocked, flash the f-droid zip package and then you don't even need to enable third party apps and F-Droid will be even more enjoyable to use.

[1] https://f-droid.org/en/packages/org.schabi.newpipe/

[2] https://gitlab.com/fdroid/fdroiddata/tree/master/metadata/or...

[MayeulC]

I've found that the Magisk module for the f-droid priv-ext tends to work better than the OTA for Android 10.

[jraph]

Exactly. The ota was not yet updated to support android 10 last time I checked and paths have changed.