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by dragonwriter 2164 days ago
> Those places already have herd immunity.

No, they don't, or they wouldn't have new cases, even without even somewhat looser mandatory controls than other places. What they have is some degree of immunity in the population (not herd immunity) plus (in some subset of those places) some degree of contact tracing backed by targeted mandatory, or at least voluntary, quarantines/isolation of the exposed, and (in large part because of the intense impacts each has had) voluntary general distancing.

3 comments

You sound very confident. There are some epidemiologists at the University of Oxford who disagree with your definitions.

https://www.medrxiv.org/content/10.1101/2020.07.15.20154294v...

> No, they don't, or they wouldn't have new cases, even without even somewhat looser mandatory controls than other places.

That's not what herd immunity means.

The Herd immunity threshold is attained when the R factor drops below 1, assuming otherwise uninhibited spread. The threshold for herd immunity for COVID-19 has been estimated at 50-80%, but that is assuming an R0 that is likely overestimated.

Given that spread is still mitigated by certain interventions, and since we don't know the impact of those interventions on R, nor do we know R0, we don't know if we have herd immunity. However, we do have R below one in many European countries.

Herd immunity isn't a binary threshold after which zero cases occur. Even in a first-order homogeneous and well-mixed SIR model, you may asymptotically approach 1 - 1/R0 of the population infected without ever getting there. If you do cross that threshold ("overshoot"), then the case count starts to drop, but new people still get infected and die on the downslope. The only case where a disease will naturally burn itself out abruptly is if there was massive overshoot, which would be bad, because it means yet more people died than necessary for natural herd immunity.

And for real some people have many more contacts than others (nurses, police, etc.). They get infected first, with disproportionate harm, but then become immune first with disproportionate benefit. That heterogeneity means 1 - 1/R0 is potentially a significant overestimate of the share of the population that needs to get infected for herd immunity, but there have been very limited efforts to quantify that so far.

It seems like some people believe natural herd immunity (from recovered patients) could work like vaccination does, to effectively eradicate the disease? That's probably false--the most likely natural endgame would be that the coronavirus becomes endemic, always present with some low incidence, with continuing mortality that's very low (because the incidence is low, and because older people probably benefit from immunity from when they were younger and the IFR for young people is <1/100 of older people's) but nonzero.

Finally, herd immunity and interventions (social distancing, masks, etc.) work together. It's possible (and likely I believe) that in hard-hit areas that now show R ~ 1, this is due to the product of both factors, and that either relaxing to their previous lifestyle or applying the same interventions in a naive (100% susceptible) population would show R > 1.