[s1artibartfast]

>Personally I would absolutely consider persistent misery, or experiencing extreme sadness over minor things, to be a clear proof that there is something wrong with my brain. Whether I treat that with therapy or medication, I think that is very much worth treating, and definitely not worth simply accepting.

I think you are making the assumption that it is treatable, or that the treatment advantages outweigh the disadvantages, which is not always the case.

I think there is a general over-subscription to the idea that everything can be treated or optimized. Some diseases are incurable and sometimes a personal optimal is still poor compared to average.

[all_blue_chucks]

Not all cases of depression are effectively treated - some end in suicide - but every single case is worth treating. Resigning oneself to lifelong misery is the worst possible choice.

[s1artibartfast]

That depends on the side effects of the treatment and how bad the depression is