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by iskander
2168 days ago
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Illumina error rates are <<1% (~0.1%), whereas Nanopore with newer basecalling software is 5-10%. With UMIs you can get a consensus error that's also <<1%. The error profiles are indeed different: Illumina generally creates substitution errors, whereas Nanopore has trouble with "homopolymers" -- counting how many of the same letter occur in a row. |
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