Screenreaders (including free and built in ones) have had JS support for quite a while. Using JS is very far from being the limiting factor for robust accessibility.
I wonder who bothers to test their wonderful experience product on a screenreader. Regardless of this and regardless of the security threat JS execution poses, I find it hard to use the internet with JS disabled.
However, when it comes to SPAs, I find that I like the older version of the website way more and also find it a whole lot more intuitive and usable.