[virtuallynathan]

“piercing the lumen” is a drastic over-simplification. We don’t know how much LDL is in a healthy lumen (the small amount of research that exists suggests its greater than the serum concentration). Much of it gets there via active transport mechanisms (transcytosis).

Also, why would an endogenously produced protein end up killing you? Seems like evolution run-amok.

[rantwasp]

haha. it’s amazing how complicated even the simplest forms of organic life are. things do go wrong all the time and there are complex mechanisms to balance things out. that being said systematic imbalance or just “wear and tear” eventually win.