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First that page shows a maximum daily dosage of 400mg/7 (weekly dosage) in adults. What's being used in covid patients is 800mg/day for the first day [1]. Can you point to any studies that shows the safety of hydroxycholorquine in people with respiratory distress or infection? Can you show any studies that hyrdoxychlorquine is safe when the blood oxygen level drops below certain level often seen in covid patients? Can I point you to here which shows all the potentially dangerous side effects of hydroxychloroquine? [1] https://www.pdr.net/drug-summary/Plaquenil-hydroxychloroquin... Interesting aspect is the following: > Hydroxychloroquine prolongs the QT interval. Use hydroxychloroquine with caution in patients with conditions that may increase the risk of QT prolongation including congenital long QT syndrome, bradycardia, AV block, heart failure, stress-related cardiomyopathy, myocardial infarction, stroke, hypomagnesemia, hypokalemia, hypocalcemia, or in patients receiving medications known to prolong the QT interval or cause electrolyte imbalances. Females, geriatric patients, patients with sleep deprivation, pheochromocytoma, sickle cell disease, hypothyroidism, hyperparathyroidism, hypothermia, systemic inflammation (e.g., human immunodeficiency virus (HIV) infection, fever, and some autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus (SLE), and celiac disease) and patients undergoing apheresis procedures (e.g., plasmapheresis [plasma exchange], cytapheresis) may also be at increased risk for QT prolongation. |