[rezna]

No longer need for hundreds of thousands. The aim is for just few thousands in few hours to reach acceptable resolution.

The development goes real fast with both SW and HW.

[COGlory]

Depends greatly on whether or not what you're imaging has symmetry.

[rezna]

You can see that the record tests are being done with apoferitin or gaba. It all depends on the improved qualiry of direct detection cameras, filters, things like afis, fringe free imaging, ... The innovation goes insanely fast.