[natechols]

Having worked in X-ray crystallography on synchrotrons and XFELs, I can't take the single-particle XFEL concept seriously any more. Ten years ago it seemed impressive, but the EM technology has advanced so much faster - and it's a fraction of the cost. There are some neat applications of nanocrystallography, but that too seems like a niche application now, not a magic bullet for accelerating protein structure determination.