[cj]

The study mentions 1,000 IU D3 dosage. A quick google turns up a rough figure of 60,000 IU "daily for multiple months" can become toxic.

You're probably right, most things taken at 100x the normal dose for long period of time are toxic. (Water included)

[woeirua]

Water is lethal at far less than 100x the normal dose. Google hyponatremia. You can die from ingesting a gallon of water in a few minutes.

[caseysoftware]

The largest dosage of D3 I can find on Amazon is 5000 IU in a 240 capsule bottle. To take 60000 IU, you'd have to take a dozen capsules daily, getting a new bottle every 20 days, probably multiple times.

While possible, it does seem unlikely.

[caleb-allen]

There is an interesting video about a boy who did just that, by mistaking vitamin gummies for candy:

https://www.youtube.com/watch?v=mZ6nREONy_4

[valarauko]

I'm currently taking 60K IU D3. The dosage is 1 capsule a week, for 8 weeks, and the capsules come 4 to a pack. This is followed by a maintenance dosage of 1 60k capsule once a month.

[cj]

Is this to treat a medical condition?

I'm curious why an acute high dose would be preferable over a lower dose taken daily.

[valarauko]

No obvious medical condition, other than a vit D serum level of 15 ng/mL. Depending on who you ask, that's a deficiency. I'm personally less convinced.

It's not quite an acute high dose. The body produces the equivalent of 10,000 IU per day in high sun exposure, so 60K per week tries to achieve that level. I believe the high dosage is simply convenience. The 2K IU daily dose is pretty common as well.

[gridlockd]

Sounds like he was diagnosed with a very low level of Vitamin D and got prescribed high dosage to get up to a healthy level quickly.

[jdahlin]

There are 50000 IU capsules readily available on many stores.

Taking 100000 IU per day for months/years is not necessarily toxic, especially when reducing calcium intake.

[pavs]

You can bolous dose. Depending on the which country. It might be prescription only. I take 20,000 IU once a week, 1000 iu everyday. I have bought prescribed 60,000 IU in the past.

[LinuxBender]

Just anecdotal observation, I have been taking 40,000 IU D3, 800mcg K2, 400mg Magnesium among other things, daily for 3+ years, no issue. I had to work my way up to that. I've been reversing calcium buildup in my vascular system to lower my CaC score. I know of many people doing the same thing, some longer than I have been. We are all doing good. I also stay well hydrated.

[olva22]

Sorry a bit off-topic, but what form of K2 and magnesium do you take? Can you point me to your protocol to reverse calcium buildup?

[LinuxBender]

I can point you to some of the studies on calcium removal. [1] They don't create a well defined protocol, though doctors have formed their own. I take 600mcg K2 MK-7 and 200mcg of K2 MK-4. I alternate between Magnesium-lysinate-glycinate-chelate (bound to L-Lysine and L-Glycine) and Magnesium Citrate. Since I am listing papers I have to point out that I am not a doctor and this is not medical advise. This method has been working slowly for me and faster for others, likely due to epigenetic and environment factors. I take these things with fatty meals to allow D3 binding and absorption.

[1] - https://www.google.com/search?hl=en&source=hp&biw=&bih=&q=si...

[olva22]

Thanks so much! Really appreciate the info.

[econcon]

Higher ones can be found at a pharmacy