[EvanWard97]

`But those animals that do live at depth will clearly need some special adaptations, says Dr Jamieson.

"They'd have to do something clever inside their cells. If you imagine a cell is like a balloon - it's going to want to collapse under pressure. So, it will need some smart biochemistry to make sure it retains that sphere," the scientist explained.`

I don't understand how octopi would need special cellular adaptations for living at t those depths. So long as their cells do not require air cavities (fairly certain they don't), I can't see what the issue could be. Differential pressure can cause problems, but there's no delta-p when your cells are equally incompressible solids and liquids.

I hope that I'm wrong though and that this scientist isn't as mistaken as they sound.

[neurostimulant]

High hydrostatic pressure seem to affect cell morphology, possibly due to changes in protein shapes while under extreme pressure. I only did some cursory googling and found several research papers about how pressure affecting cell morphology, for example this one on epithelial cells: https://pubmed.ncbi.nlm.nih.gov/3052872/

> At atmospheric pressure, cells were flat and well attached.

> Exposure of cells to pressures of 290 atm or greater caused cell rounding and retraction from the substrate.