[partyboat1586]

With naturally skinny people having less flexible adipocytes does that not put them at higher risk of diabetes? Since they have less area to store the fat they will more quickly reach their threshold and start developing insulin resistance. Why then is there a classical association between obesity and diabetes? Or perhaps the definition of obesity is flexible depending on genetics?

On the topic of refined sugar my understanding was that because it is processed by the body more quickly it spikes blood sugar levels short and sharp rather than more spread out in the case of protein and fat which take longer to digest. Because of the limited rate of creating adipocytes this means that the same concentration of blood sugar delivered over a shorter time period would stimulate insulin resistance where if it were delivered over a longer period of time blood sugar levels would not cross that threshold. I'm sure that if you eat a caloric surplus that you will trip the threshold but could it not also be tripped by eating lots of high sugar foods to the same amount of calories of fat and protein which would not cross the threshold?