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by Trasmatta 2217 days ago
> Insulin Resistance is the start of (all?) metabolic disease. So easy to resolve using fasting, intermittent fasting, keto, carnivore etc diets.

Definitely not all. Not the least of which is Type 1 Diabetes, which is marked by the inability to produce insulin, not insulin resistance. And it's currently impossible to resolve, all Type 1 Diabetics have to be on insulin therapy to survive.
3 comments
ashtonkem 2217 days ago
Is Type 1 diabetes considered a metabolic disease? I've only heard of "metabolic disease" in reference to "metabolic syndrome", the precursor to Type 2 diabetes and heart disease.
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asplake 2217 days ago
There are many metabolic disorders - some due to specific genetic issues, and some severely life-limiting (eg children unlikely to reach adulthood). And as per the Wikipedia page for metabolic disorders, not to be confused with Metabolic syndrome or Diabetes.
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Trasmatta 2217 days ago
It's a metabolic disorder. I guess I don't really know the difference between metabolic disease / metabolic syndrome / metabolic disorder. All problems of the metabolism, but I'm sure there's some medical distinction between them.
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dreamcompiler 2217 days ago
> And it's currently impossible to resolve, all Type 1 Diabetics have to be on insulin therapy to survive.

Not quite impossible but granted, islet cell transplants are still experimental.

https://en.m.wikipedia.org/wiki/Islet_cell_transplantation

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Trasmatta 2217 days ago
True, technically it's also possible to get a pancreas transplant. But in both islet cell and pancreas transplantation, the risk of rejection and the burden of immunosuppressive regimens are high enough that they are rarely ever recommended for T1 diabetics. From my understanding, it's usually only recommended for a diabetic requiring some other transplant at the same time (since they'll have to be on immunosuppressive drugs anyway).
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bad_user 2217 days ago
T2D also leads to impaired insulin action, when the beta cell function of the pancreas is impaired.

Sometimes impaired insulin action comes before insulin resistance and it is still T2D.

The difference is that T1D is an auto-immune disease, wereas T2D is caused by energy poisoning.

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