[thmzlt]

I wrote a tutorial the other day on using Nix to handle the Python package situation. No need to install Python or even touch pip:

https://thomazleite.com/posts/development-with-nix-python/

[silviogutierrez]

+1 for nix. Nothing comes close. Pain to first learn it though.

But now you have truly deterministic builds.

Well, almost. Don't forget to pin channels.

[zcoyle]

There is also the wonderful poetry2nix project: https://github.com/nix-community/poetry2nix