[microtonal]

My current hurdle is exactly the topic of this thread: non-binary configs. For example, what am I supposed to do with .zprofile? I think I’m supposed to write a custom Nix derivation for ZSH that includes any and all customizations. I’m concerned that might cause problems with MacOS system ZSH. I can probably fix that with a custom login shell?

I use both NixOS and macOS. You can take two routes: 1. you can continue using Apple's /bin/zsh and just use a .zprofile generated using Nix (e.g. home-manager). Generally, the differences between zsh versions are not that large and it just works. This is what I have been doing with my Mac. 2. You could change your shell, either system-wide, or just for Terminal.app to ~/.nix-profile/bin/zsh.

I’ll eventually move to NixOS. I tried to run NixOS in VirtualBox, but couldn’t get screen resizing to work despite using the official ISO which is supposed to have the appropriate extensions installed.

If you have some leftover hardware, try it! NixOS is a different experience altogether and cannot be paralleled by Nix on macOS or a Linux distribution. Being able to declaratively define your whole system is insanely cool and powerful. Fully reproducible machines. Also, you can try out stuff without any harm. Just switch back to the previous working generation (or try the configuration in a VM with nixos-rebuild build-vm) if you are not happy.