[kolinko]

One thing would be seeing a significant mutation appearing in the wild, and noticing that people with that mitation have less symptoms.

For covid, the mutations were minimal, which makes sense - the virus’ construction make it unlikely to mutate (unlike flu).

[Touche]

That wouldn't make the virus disappear though, it would make it less severe. Which is good! Hopefully that happens. That it mutates to the point of being significantly less deadly before a vaccine seems unlikely to me.