[epistasis]

A lot of people in bioinformatics use SnakeMake. In this field you often want to restart analysis after something changes somewhere along a pipeline (for example the pipeline is under active development and changing frequently), and individual steps can take hours or more, so automatically rerunning just the right stuff is a great feature.

However, SnakeMake, Nextflow, etc feels excessively verbose compared to standard make. And the prior workflow managers of last decades were far worse. With standard make, you type pretty much exactly what you would for shell commands, and not too much more.

All other alternatives are going to be more verbose than make, and to me that's a negative.