[thu2111]

I don't know what they think. How would I? Do you think the anti-vaxxer viewpoint is covered by the media, do we ever discuss it here on HN, is it something that's a part of mainstream debate? No, it isn't.

These people never really get taken seriously regardless of what claims they're making. The moment a position starts being labelled quack/crank/dangerous misinformation, you're already at the point of "coarse" characterisations, or mis-characterisations.

So now look what's happened. Apparently there are two kinds of anti-vaxxer, the ones worried about "proven risks" and then the real cranks making "paranoid claims". But the sort of anti-vaxxers who would have been refusing to give their child Pandemrix before it was understood to be linked with higher narcolepsy rates would have come across as paranoid, wouldn't they? They'd have had to say something like:

"I don't know. It's a new vaccine. It might be dangerous. I'm not sure swine flu is dangerous, I'd rather not vaccinate my child."

and they'd have got an answer from us HN-reading types of the form:

"Swine flu is very serious, the WHO has declared a global pandemic and clinics are being overwhelmed with infected people. Vaccines are well understood and very safe. Experts say the MMR scare was just debunked crank science. If you don't vaccinate your child you're an ignoramus who is putting both your child and other people at risk, you shouldn't even really have a choice. I will report your tweets to Twitter for misinformation."

And we'd have been wrong and they'd have been right.

https://en.wikipedia.org/wiki/2009_swine_flu_pandemic#Histor...

"The Mexican government closed most of Mexico City's public and private facilities in an attempt to contain the spread of the virus; however, it continued to spread globally, and clinics in some areas were overwhelmed by infected people ... In late April, the World Health Organization (WHO) declared its first ever "public health emergency of international concern," or PHEIC,[38] and in June, the WHO and the U.S. CDC stopped counting cases and declared the outbreak a pandemic"

[rleigh]

I disagree that the "anti-vaxxers" would have been "right".

They fail to trade off the risks appropriately.

No one can claim vaccines are "safe". They induce a host immune response so that the immune system is primed to fight a subsequent infection. The immune system can cause damage to the host, which is why we have a whole catalogue of autoimmune disorders, many of which can be modulated by infectious diseases and parasites. There is a risk a vaccine could induce a host immune response which causes damage. But it's a small risk.

You have to trade off the risk of vaccination with the risk of being infected with the disease, and the risk to society at large through spread of the disease when vaccination rates are too low.

In pretty much all cases, the risk of the disease is many orders of magnitude higher than the risk of the vaccine. If there's a 0.000001 chance of the vaccine causing problems vs a 0.0001 of dying or suffering long-term damage from the disease then the choice is obvious: get vaccinated.

Unless the "anti-vaxxers" are basing their arguments upon quantitative data, then I'll continue to view them as crackpots with little knowledge or understanding.

(I'm an immunologist, by the way.)

[sifar]

>> If there's a 0.000001 chance of the vaccine causing problems vs a 0.0001

The problem is how do I trust these numbers. That the vaccine risks aren't underestimated and the disease damage over-estimated. Something that can be confirmed only when enough time/data has elapsed.

The current pandemic is an example. Almost everyone who publishes data has some motive to push a viewpoint (knowingly or unknowingly). It will take some time before one can trust the data and its inferences. But then meanwhile, one is being asked to trust the experts who are not open about the data and methodologies.

[thu2111]

No one can claim vaccines are "safe".

Of course not, but they do anyway as I'm sure you must know!

Imagine someone who is just starting to worry about vaccines does a google search and ends up on this top result:

https://en.wikipedia.org/wiki/Vaccine_hesitancy

It says: "Arguments against vaccination are contradicted by overwhelming scientific consensus about the safety and efficacy of vaccines.[5][6][7][8]"

The first citation for this claim is an article on the WHO website which quotes Dr Giovanni Rezza, Director of the Department of Infectious Diseases at Italy’s National Institute of Health. He says:

"The media often sets up a false opposition between public health officials and anti-vaccination campaigners, rather than conveying a clear message that there is an overwhelming scientific consensus in favour of nationally recommended vaccines"

Scientists are quite happy to insist that there's no debate to be had at all; this is very far from it being all about relative risks which reasonable people can disagree on.

Unless the "anti-vaxxers" are basing their arguments upon quantitative data, then I'll continue to view them as crackpots with little knowledge or understanding.

I assume any anti-vaxxer with any knowledge would cite a case like Pandemrix, which does have quantitative data. In fact DanBC provided some: maybe 5000 long term cases in the USA if everyone had been vaccinated. But I think you must admit, clear data is a luxury that nobody seems to have about viral spread. The numbers for how many people got Swine Flu vary dramatically depending on who you ask, even today. If I were asked to support an anti-vaxxer in a debate, I'd point out there's no reason to believe scientists can accurately weigh the costs and benefits of vaccines given their inability to even tell us accurately how many people die of the flu each year, and the fact that diseases caused by vaccines only become widely accepted years after the fact.

[DanBC]

To me the point that pandemrix makes is that regulation works.

We lowered the amount of regulation in order to release pandemrix because of the pandemic. We see (even on HN) calls for a similar relaxation of regulation during covid-19.

Pandemrix did cause harm. It caused severe harm. But it was withdrawn because of the harm it caused.

The people opposed to vaccination are not saying "vaccination is mostly safe but rarely causes harm", they're saying "vaccination is massively unsafe".

Narcolepsy caused by pandemrix affected about 1 in 50,000 people who had the vaccine. People opposed to vaccination aren't talking about narcolepsy. They talk about autism -- and there are very many studies that show that vaccines do not cause autism.

And all of those studies showing safety are in addition to the uncovering of the deception and unethical practice that Wakefield was involved in.

And don't forget that Wakefield wasn't anti-vaccination. He was developing his own measles vaccination, and he had to show that MMR was dangerous if he had any chance of getting his own vaccine approved and used.

[0xddd]

So you're relying entirely on conjecture of this possible conflation and not weighing how much more dangerous one side is compared to the other? I'd find it much more useful to discuss if there examples of this being an actual widespread problem, where people with rational concerns were getting put down and lumped in with the antivaxxers. Until then, anyone promoting the MMR/autism link which stems from a downright fraudulent study by a corrupt author deserves every bit of pushback that they get.

[thu2111]

And how dangerous are the two sides? Can you quantify that? I've never seen the anti-vaxx debate turn into a civilised discussion of balanced risks vs rewards. It's always a pile on against "science deniers".

I think I just gave you an example. Anyone who objected to Pandemrix on the principle that they were an anti-vaxxer would have been classed as a paranoid anti-science crank right up until it turned out, whoops, there actually was a problem with it, at which point they magically changed into people with "rational concerns".

That's obvious now but it wasn't at the time when it actually mattered: at the moment children were being injected with it.

How many anti-vaxxers have you talked to personally? For me I must admit the answer is none. I know these people exist only through media reports. I no longer trust the media, especially when it comes to the matter of "experts" and their reliability, so that's already a bad start. So are you sure MMR is their only reason for concern, or is that a "crude mis-characterisation" designed to dismiss them? There was an anti-vaxx movement in the USA before Wakefield so it's unlikely that's the only thing that motivates them.

Heck, how sure are you about the details of the whole MMR incident? Was Wakefield truly discredited? Remember that as far as the official establishment is concerned Professor Ferguson is still a reputable expert with an excellent reputation, and I definitely don't believe that, so apparently what the academy thinks of scientists isn't all that reliable.