There are gaming consoles, or you can just not run their games, it's not like there aren't literally thousands to choose from. They're also just games, cheating is not a life or death thing, or it shouldn't be.
Alternatively, you could stream a game from a remote server like on Stadia. These anti-cheat systems are only for online games anyway, and you can let Google deal with their kernel driver.
"annoying" when dealing with graphics cards / passthrough if you're talking about virtualization and probably would not be allowed since the hypervisor would be a ring above the kernel module, effectively neutering it.
If you mean dual-boot, sure, that's a very reasonable solution as well. I just don't like to reboot often and would personally have a 2nd computer as it probably takes me an hour or more to go from "booted" to "productive"