|
|
|
|
|
|
by legolas2412
2253 days ago
|
|
|
Thanks for your answer. I'll like to point out that 3 is slightly eased off if the two viruses are already able to jump to humans. In this case, it could be the SARS coronavirus and the pangolin virus whose receptor proteins are similar to ncov19. Then all that is required is for the two viruses to jump over and then recombine. Definitely a possibility. I find the wet market theory full of such improbabilities too. How is ncov19 relatively close to two known viruses, 1) the sars like bat virus it was 96% similar to, and 2) the pangolin virus with which it has resembling receptor proteins. Seems a lot of coincidence for these two to combine, both of which can jump to humans, and 300 meters from a leading Coronavirus research lab. I know I'm just repeating the conspiracy theory, but just explaining my position. The virus was found initially at the wet market, and there is no proof of its origin being there. Plus it seems perfectly feasible for it come out of the lab and not be a deliberately engineered virus, atleast not one using the 2019 paper's chimera virus techniques. |
|
|
Those same traits also produce a high degree of similarity between a lot of genomically differentiable strains of coronavirus, especially since spike proteins tend to be strongly conserved for their direct effect on virulence - a significant mutation there is likely to be maladaptive, if it changes the protein structure enough for cells to no longer uptake a virion that expresses it. So it's not really a surprise to see that two different strains have similar spike proteins, and doesn't really give much basis for inference about relatedness between them.
Another important point is that coronaviruses are so common specifically in bats, which are both extremely plentiful and unusually accommodating hosts for many kinds of viruses including coronaviruses, very often with multiple strains infecting a single host at once. That gives coronaviruses - which, remember, are already good at recombining to produce new strains, every one being possibly able to jump species - more chances at that kind of recombination than they would have otherwise.
Too, bats shed virus in feces the same way humans do, and bat guano is so effective a fertilizer that wars have started over access to supplies of it. So it's not difficult or unlikely to postulate a chain of events like this:
- a recombination event in a bat produces a virus capable of infecting humans,
- which is then deposited in feces used to fertilize a human food crop,
- which is then harvested and taken to a city market to be sold,
- and all it takes for someone to get sick from there is not washing their hands often enough while they're cooking.
To be clear, I'm not saying this is what happened. Nobody knows that yet. But precisely because nobody knows that yet, it's important to consider the relative likelihoods of various ways that the pathogen might have developed into a form that can infect humans, and then reached the point of actually doing so.
That's what I'm doing here. Each stage of this postulated chain of events relies only on things that are already known to frequently occur, and have been so known since long before SARS-CoV-2 was even known to exist.
The result is unprovable, of course, just as with every other theory of this disease's origin that anyone has advanced so far. But it doesn't rely on any unusually small probabilities, and so it seems a lot likelier to me than the combination of a lab accident of a kind known to have happened only a few times in the last two decades, and a simultaneous superinfection of a single researcher with two different strains of coronavirus.