[not_exactly__]

CMilk did a video a week or two ago on what evidence we have so far. I’d say it’s convincing enough; or rather, that within the context of China, there is enough smoke (disappearing lab members, papers removed...etc), lots of CCP efforts to call those rumors, and not much dispelling being done by the government. In all my years in China, if there’s one thing the government there hates, it’s rumors and they will do anything to squash them if they’re actually false (eg providing proof of life if people claim someone is missing vs just saying “I assure you they is alive.”)

[throwanem]

Can we please cite something a little more substantive than random Youtube videos made by people with no apparent familiarity with the fields of endeavor they're trying to report on? I mean, I don't doubt the guy's good intentions, but this is like if I were trying to make a technical argument about the physics of string theory.

[Wimpzilla]

Well, one can easily dig into the sequences database, to find some useful clues:

-A lot of chinese papers have been published through the years on the topic, during multiples waves of sample collection over all the chinese mainland. Showing there was/is a notable interest about this pathogen issue.

-One can also easily spot which research center were/are the most active on the topic and its related research teams. Wuhan research center is not excluded from the list as some others main big labs.

-Each entry sequence in the database is dated with a location, publishing team and associated paper. It is useful for following the pathogen evolution building phylogeny trees.

-Aligning a lot of sequences clearly show that this strain is separated from the rest of the others mains strain. The only related sequences are the one released by the chinese team.

-The closest related sequences are 2013 year dated and other from 2015/2017/2019, which per se does not provide a lot of information about the real pathogen evolution.

-The different gain of function that this pathogen got compared to its predecessors is quite remarkable and hard to overlook.

-The overall AT/GC sequence content have also evolved from its predecessors showing rich AT content that is generally related to higher host habit and expression.

So yeah, knowing china is not smiley kind shaped, one can still question the research and lab habit as one would do for any other country. A theory based on excessive and unregulated animal sampling could have exacerbated the real cross-transmission issue is as valid as the one about pathogen leaking from the lab or simply by natural evolution.

Anyway one can clearly take a moment to question the overall package, along the safety lab practices deployed around the world when dealing with potential pathogens.

[throwanem]

I'd be interested to look at that sequence comparison in more detail. IIRC you can link BLAST results etc. directly from NCBI's site, and I'm sure you can link the sequence accessions to which you refer.

[Wimpzilla]

Looking very carefully and with patience one can find everything on NCBI database. Otherwise there is a big repository of sequence here: http://www.mgc.ac.cn/DBatVir/

[throwanem]

Yes, but the NCBI sequence database is quite vast. You seem already to have gone to the effort of finding and reviewing these sequences, and producing an analysis. Why not share your sources as well as your results, instead of asking others to find them from scratch and have to hope they're the same ones you're using?

[baddox]

But the fact that a government sometimes tries to cover up things does not mean that every claim is true. “They’ve covered stuff up before” just is not sufficient evidence for anything, including, say, Bigfoot.

[not_exactly__]

We are not judging the validity of the claim from the claim alone. We are doing so from the pattern of behaviors around it by the CCP and how those patterns correlate to priors we’ve seen in the past when they’ve tried to hide the truth.