[anyfoo]

What a terrible condition. To me, a chronic insomniac (with fortunately absolutely no indication or family history that what I have is anything more than chronic, but intermittent insomnia), FFI always seemed like the grotesque conclusion of insomnia, actually driving people insane and literally killing them for lack of sleep. Which this article seems to confirm.

[Konohamaru]

All prion diseases are kind of similar, but no, I don't think FFI is the worst of them. The defining feature of FFI is rapid dementia and then death, not necessarily insomnia.

I think Mad Cow Disease (new variant Creutzfeldt-Jakob Disease) is the worst of them.

* Protracted course 1+ year from onset to death. Maybe 1.5 years is not unheard of.

* Almost purely psychiatric issues at the start, not even cognitive.

* But it ends in akinetic mutism, which is when you want to move, but a counterwill energes preventing you from moving, and you want to speak, but a counterwill prevents you from speaking. Locked-in syndrome.