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by cincijones 2258 days ago
This is totally incorrect. First, the MOA of hydroxychloroquinoline (HCQ) in malaria is completely incorrect. It works through lysosomal function regarding the presentation of antigens to the immune system. Secondly, Covid-19 is not a DNA virus but an RNA virus, DNA is not involved nor is an interaction with hemoglobin involved in the anti-malaria activity of HCQ. There is nothing in the scientific/medical lit as of today about any interaction with hemoglobin and covid-19, nor any reason to think HCQ would interfere in such process. (WKJ, Professor of Pharmacology)
1 comments

I believe this paper qualifies as scientific/medical lit:

COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism SOURCE: https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surf...