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by pazimzadeh 2268 days ago
I haven't seen any evidence that (Xydroxy)chloroquine alone directly inhibits anything to do with the viral replication. The closest thing that I found is that Thymoquinone inhibits Mouse coronavirus replication and is generally protective of lungs:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933739/ https://erj.ersjournals.com/content/50/suppl_61/PA4935

Chloroquine is an antipyretic and relieves symptoms like fever from diseases like Malaria and dengue.

Chloroquine stops the inflammation from going out of control, which a good thing during an infection. But if you take it when you don't have an infection, it could stop you from detecting viruses in the first place.

The paper I cited in the previous comment mentions that Chloroquine is a TLR7 inhibitor. TLR7 is a receptor that senses of single-stranded viral RNA. https://www.sciencedirect.com/science/article/abs/pii/S01663...