""" Guided by the principle ofprimum non nocere (first do no harm), we report a cautionary note on the potential fatal toxicity of chloroquine (CQ) or hydroxychloroquine (HCQ) in combination with anti-diabetic drug metformin. We observed that the combination of CQ or HCQ and metformin, which were used in our studies as potential anti-cancer drugs, killed 30-40% of mice. While our observations in mice may not translate to toxicity in humans, the reports that CQ or HCQ has anti-COVID-19 activity [1], the use of CQ resulting in toxicity and at least one death, and the recent Emergency Use Authorization (EUA) for CQ and HCQ by the US Food and Drug Administration (FDA) prompted our report. Here we report the lethality of CQ or HCQ in combination with metformin as a warning of its potential serious clinical toxicity. We hope that our report will be helpful to stimulate pharmacovigilance and monitoring of adverse drug reactions with the use of CQ or HCQ, particularly with metformin.
"""
Maybe just read the introduction instead of writting this kind of complotist nonsense? I know that's not the first thing to read in a usual, well-written scientific paper, but there is a lot of papers about covid19 everyday and clinical papers are weird anyway.
HCQ enters trial testing and if we can reduce the number of trial death due to wrong medicamental interactions, it will probably boost the survival of tested people using HCQ, so even if a conspiracy exist, you should be happy that paper like this exist, no?
A thing i saw that works against a conspiracy against HCQ is that on french and US website, everyone is talking about HCQ, well or not, but a lot of other, poorer countries put their hope on interferon (as i do: i take chlorphetamine and other antihistamin drugs that can cause tachycardia especially in spring/summer, and i have arythmia => i'd like to avoid another drug with heart-related secondary effect, my kidney and may spleen are in perfect condition, i'd rather ruin them)
If i couldn't read spanish, i wouldn't even know about interferon tbh, it's much more promising that HCQ: like HCQ it works in vitro against HIV, but unlike CA that agravate AIDS, interferon works in vivo too. Here an AFP article about interferon and sras-cov2 (spanish, works with google translate: https://factual.afp.com/el-antiviral-cubano-interferon-alfa-...)
Maybe just read the introduction instead of writting this kind of complotist nonsense? I know that's not the first thing to read in a usual, well-written scientific paper, but there is a lot of papers about covid19 everyday and clinical papers are weird anyway.
HCQ enters trial testing and if we can reduce the number of trial death due to wrong medicamental interactions, it will probably boost the survival of tested people using HCQ, so even if a conspiracy exist, you should be happy that paper like this exist, no?
A thing i saw that works against a conspiracy against HCQ is that on french and US website, everyone is talking about HCQ, well or not, but a lot of other, poorer countries put their hope on interferon (as i do: i take chlorphetamine and other antihistamin drugs that can cause tachycardia especially in spring/summer, and i have arythmia => i'd like to avoid another drug with heart-related secondary effect, my kidney and may spleen are in perfect condition, i'd rather ruin them)
If i couldn't read spanish, i wouldn't even know about interferon tbh, it's much more promising that HCQ: like HCQ it works in vitro against HIV, but unlike CA that agravate AIDS, interferon works in vivo too. Here an AFP article about interferon and sras-cov2 (spanish, works with google translate: https://factual.afp.com/el-antiviral-cubano-interferon-alfa-...)