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by joyj2nd
2263 days ago
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"liquid chromatography, is frequently used. On a small scale this is fine, but when kilograms of material are required the process becomes unwieldy." I did not understand this. liquid chromatography scales up quite well. There are other methods like Electorphoresis, salt precipitations etc., that don't. |
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Not compared to recrystallization or distillation. Try running a column on 10kg scale and get back to me.
(I worked in an o-chem lab for 2 years in undergrad, and the biggest we could do was ~20 grams at once)