[biophetik]

Protein folding is part of it. The other is finding which parts are antigenic to the immune cells. Epitope mapping is a common method to screen small bits of the proteins to see if any are hits for immune cells to recognize and kill. There are algorithms that can take the RNA/DNA, predict proteins, and then guess a percentage of those that may be important. But you still need to synthesize those in mass quantities and start testing each. Once you have candidates you then test them in mouse models (typically) to see if they actually provide an immune response. If interested check out the iedb. https://www.iedb.org/