As a Canadian, does the lack of a college degree significantly act as a disadvantage for visa programs such as TN/H1-B ?
In the case of a pressing move to the US, what would be some options for someone with no degree?
That's correct, you can still qualify for an L-1 (as a transferee after 1 year of employment outside the US) even if you don't have a degree and there are TN occupations that don't require a degree. Further, you can get an O-1 without a degree as well as an H-1B as long as (in the H-1B context) you have the equivalent of a bachelor's degree (essentially 12 years of professional experience).
I think things can be easier once you've worked for the company for over a year