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by bionhoward 2278 days ago
Biased as an immunologist, but this sounds like HLA type differences. The cells chop the virus proteins and stick them out using MHC1 to notify the immune system. This response is partly determined by genetics (HLA TYPE) and if we cluster outcomes vs HLA types we could learn a model to predict who’s gonna have worse outcomes. Could help with triage if it were a decision tree model
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Somewhat distantly related, have you seen https://www.reddit.com/r/COVID19/comments/fjzjpc/relationshi... ? (also see the old sars paper my comment cites and the surrounding thread)
It could also inform people to help them make decisions. IE: if they are more at risk they take more precautions and vise-versa.