[CriticalCathed]

>Hydroxycholorquine is interesting [1] both as an anti-inflammatory and immune modulator. The Azithromycin probably does nothing against nCoV-2 but may well help control secondary infection.

I had no clarity as to why azithromycin had improved the outcomes in that study to 100% of those treated with it, when HCQ didn't. That's very interesting.

Maybe you could clarify something else for me. Is there any information about whether these two drugs together could function as a prophylactic, or is this something patients have to be administered at the beginning of symptoms, or is this something that can be done late in the course of the disease?

[arcticbull]

I was speculating about the role of Azithromycin though it appears another peer post mentioned something similar. The study was only 28 patients, open-label, non-randomized, 6 of which were asymptomatic. I think it's too early to say one way or the other, the N is really small on the study.

It could easily have been that some patients in the study developed bacterial pneumonia secondary to their COVID-19 and the azithromycin treated it. Much too early to say.

> Maybe you could clarify something else for me. Is there any information about whether these two drugs together could function as a prophylactic, or is this something patients have to be administered at the beginning of symptoms, or is this something that can be done late in the course of the disease?

Wish I knew, seems to be something we'll hear more about in the near term given the interest in studying it. From what I read it works best in early stages of disease and not as well later on. While not side-effect free, they're pretty highly targeted.