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I rebuilt a house in the SF Bay Area several years ago.

In-floor radiant heating is my absolute favorite feature. Nothing like it.

On-demand tankless hot water system. With two loops (one open, one closed) and a heat exchanger between the two, one on-demand system can serve your domestic hot water plus the in-floor heating.

Humidity switches in the bathrooms to kick on the exhaust fan when moisture builds up from the shower (an anti-mold measure).

I put in structured wiring for phone, Ethernet (CAT 6), and video. I feel really stupid now as the only video I watch is on the computer and I gave up my landline to go solely cellular. I still like the Ethernet jacks in every room but mostly because I can put my wireless router anywhere. Lesson learned: technology changes rapidly. My structured wiring box looks quaint instead of high-tech after only five years.

A solar tube (basically a round skylight with a thirty foot reflective tube) that brings natural light down to ground floor rooms. Very nice.

One piece of advice: Don't get started on house remodeling or construction if you're doing a startup or trying to run a business. It tends to demand far more time than you have. And it's true it can put a strain on relationships (for the same reason).