i currently take Plaquenil (Hydroxychloroquine) for rheumatoid arthritis, and my doctor did indicate it may be helpful against Covid but not enough tests to confirm. Is it close enough to chloroquine to be the same ?
Keen to know this too. Hydroxychloroquine is the only common -quine drug in East Africa; odd but true, I think malarial chloroquine resistance has something to do with lack of demand/supply.
Additional possible drugs are alluvia, actemra. I think there's a study out for alluvia.
Things to avoid are aspirin (suspected basses on [1]) and ibuprofen (French govt recommendation).
Someone should come up with a summary page of the potential therapeutic drugs and their current state (suspected/in study/recommended)
"Hydroxychloroquine (EC50=0.72 μM) was found to be more potent than chloroquine (EC50=5.47 μM) in vitro. Based on PBPK models results, a loading dose of 400 mg twice daily of hydroxychloroquine sulfate given orally, followed by a maintenance dose of 200 mg given twice daily for 4 days is recommended for SARS-CoV-2 infection, as it reached three times the potency of chloroquine phosphate when given 500 mg twice daily 5 days in advance."
(NOTE: I am not a medical practitioner, I'm just parroting what I was told in a video)
The Medcram video shared elsewhere in this thread (https://www.youtube.com/watch?v=U7F1cnWup9M) does mention that hydrochloroquine is a relative of chloroquine and is also being administered in some places when chloroquine is not available (at a different dosage). They take pains to point out that they should not be administered at the same time as that can lead to a fatal complication, and also that chloroquine as a treatment overall has not been subjected to a rigorous medical study.
The paper says clinical tests used both chloroquine and hydroxychloroquine. In discussing the results, they don't seem to differentiate between the two, unless I missed it.
And as discussed previously before in many submissions, hydroxichloroquine is already actively being used against Covid19 by at least the following EU countries:
Additional possible drugs are alluvia, actemra. I think there's a study out for alluvia.
Things to avoid are aspirin (suspected basses on [1]) and ibuprofen (French govt recommendation).
Someone should come up with a summary page of the potential therapeutic drugs and their current state (suspected/in study/recommended)
Sorry for the brevity. On a phone.
1. https://academic.oup.com/cid/article/49/9/1405/301441?fbclid...