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by jaaames 2282 days ago
I am extremely bearish on this whole global situation, but given the gravity of the situation, we're going to see the world's best institutions and minds working on vaccines and treatments with essentially unlimited funding and top priority.

Even during our darkest times, we're going to see the most remarkable science and engineering capabilities exposed in the coming weeks and months, for the sake of humanity.

9 comments

Reading about Russia sending rockets to Venus in the 1960-70s [1], then later watching a documentary about the Viking program [2], was one of the things that cheered me up the most during this whole thing.

Humans have done amazing things in the face of dire odds. Nothing brings them together like these sorts of challenges.

Since then I've been reading a book called "The Rise and Fall of Dinosaurs" and there's been so many extinction events, yet life still bounced back each time stronger than before. Looking at life on that timescale, what humans managed to accomplish in such a short one doesn't get enough praise. We've only scratched the surface on how much better we could be as a species.

I'm confident we'll be far better prepared for the next epidemic and at the very least hopefully China (and others like Vietnam) will eventually ban the wildlife trade for medicine as well, not just for food. Which is what early results by scientists are pointing to as the cause of this whole thing (Pangolins trafficked for Chinese medicine). Animal conservation plays an underrated role in epidemics, same with Ebola (monkeys) and SARS (bats). We don't need to be consuming any of this stuff.

[1] https://www.youtube.com/watch?v=WlnM6kd3_n8

[2] https://www.youtube.com/watch?v=LV_xPQrQEyc

> we'll be far better prepared for the next epidemic

I agree. Being in California, it's a standing recommendation to maintain extra supplies in case of impact from wildfire or earthquake. So, I thought I was pretty well prepared. I already stock and rotate extra water, toilet paper, n95 masks, canned food, etc. But, I discovered some holes in my preparedness that I will rectify when the stores are back to normal supply levels -- I will be even better prepared for the next state of emergency.

I'm sure the preparedness will go wide and deep across many government and private organizations. At a minimum, I hope the CDC ensures there are plenty more ventilators ready for the next one.

"At a minimum, I hope the CDC ensures there are plenty more ventilators ready for the next one."

My only thought here is that we don't know that "the next one" will require ventilators. While I'd certainly like to see our national stockpile of PPE and emergency equipment like ventilators improved, I'd like to see the CDC preparing to face a wider-set of the "next one".

I think we should be looking at our manufacturing infrastructure and ability to rapidly ramp-up the production of any life-saving hospital equipment in the face of a sudden need. With a national stockpile that's strong enough to cover the ramp-up period.

You make good points, but while the "next one" may not require ventilators, it's a good bet that ventilators will be needed again. This is not the first respiratory disease pandemic.
To quality as the next one, a disease would have to spread very easily from person to person. And that usually implies airborne. Which usually means it attacks the lungs, which usually needs ventilators.

Diseases that are differently transmitted like Herpes and AIDS can be widespread, but they’re unlikely to be the “next one” because they’re easier to contain.

Depending on how you define a nebulous concept like "the next one", HIV/AIDS already is since it's a pandemic
Both influenza and coronavirus can cause severe respiratory distress. Both are subject to jumping the species barrier or mutation of existing strains resulting in higher mortality. Both are extremely infectious and very difficult to control. That's reason enough to have a few warehouses full of respirators ready to ship out. At the least we need a better plan for emergency bed space and resuscitation training for conscripted personnel.
> we don't know that "the next one" will require ventilators

Good point. How about, "the next one that needs ventilators". Either way, it is a concrete example of equipment that we can now add to the list of things we need more of to be better prepared next time, or the time after that, etc. There are certainly many more things that should be on that list too.

Specific equipment that we can buy and stockpile is one thing, but manufacturing capability seems even more important to have within our borders so we can keep making N95 masks not subject to foreign interference, in the event of a sustained epidemic.
I mostly agree with you.

One caveat though is that airborne diseases spread much more rapidly and are much more difficult to prevent than other forms of transmission.

Diseases that spread by skin to skin contact (smallpox, for instance) almost universally have visible signs before they're contagious. This makes quarantining easier.

Diseases that spread via contaminated drinking water (cholera) can almost always be stopped by boiling water or iodine tablets. And developed nations have well established ways of ensuring clean drinking water.

Diseases that spread via blood or other bodily fluids (Ebola, HIV) can be stopped by well established sanitary procedures.

Diseases that are not airborne simply don't have the potential to cause the damage covid has already caused, to say nothing of the total damage when it's all over.

Besides this, the world not just the US need standby health personnel in a similar fashion to armies. Soldiers do nothing unless needed, a "health workers" army can do the same.
This being more like a war than business as usual, the correct solution is more like the citizen armies that fought in the world wars, not a standing army.
There is no harm in having more people trained in first aid. I have to do a two day refresher in it every three years for a sports coach licence.
How much extra tax do you think people will be happy to pay -- forever, not just now while we have a pandemic on our hands -- to support this?
You question contains an implication in it that all current other tax spending will not be reduced, and that "pandemic preparedness" will have to be added to the current load.

If this goes really badly in the next couple of weeks or months, that's not going to be a true assumption. A changed nation is going to be looking at its spending priorities and a lot of reassessing will be done. Predicting exactly what the result will be is difficult, but predicting that there could be a lot of change is not.

If we cross the logistic curve's inflection point today, then this may ultimately blow over and be remembered as an inconvenience (and, humans being humans, an overreaction). If this continues on for much longer and kills hundreds of thousands and (based on some of the nasty stuff I've read about) permanently damages the lungs of millions more or other such things, causing disability and long-tail mortality increases for the next 50 years, this will be a generation-defining event comparable to the Great Depression, and the usually-reliable "tomorrow will be mostly like today" prediction methodology will catastrophically break down in the next couple of months.

given that the US has spent[0] over $5,000,000,000,000 on pointless wars, redirecting even a fraction of that toward a necessary one should be a no-brainer.

[0]: https://www.nationalpriorities.org/cost-of/war/

We just added "Space Force" so ya, why not add "Health Force" while we're at it. Health Force could have a number of tasks during non-Pandemic times too. We might even be able to pay for Health Force, at least in part, out of some foreign aid budgets if we send Health Force as part of that aid.
Yeah! Some sort of Center who's job it would be to control diseases. We could call it the Center for Disease Control.

Snark aside, we had a similar situation with SARS. In the immediate aftermath, it's easy to say what needs to be done to prevent the next one. It's far harder to get everyone onboard with paying for something 5 or 10 years down the line when "there's no point" and "why do I have to pay taxes"?

I agree, it would make too much sense to have a program of national service where people were required to undergo training for medical emergencies and disaster response. Having practically every able bodied person qualified as a first responder would pay huge dividends.
This may come across as crass but I legitimately believe that there is a market for "emergency preparedness" as a service. It can deliver a set of basic necessities at sign up and perishable supplies at regular intervals customized for your geographic location, number of family members, storage space etc. While you can do the same by trawling through prepper forums and making monthly trips to Walmart or Costco, it's not as convenient.
What were the holes you discovered?
I think there are much worse issues than just the wildlife trade. I think long-term we're gonna have a lot of issues with antibiotic resistance diseases as a result of overuse in the meat industry [1].

[1] https://www.sciencedaily.com/releases/2019/10/191009132321.h...

I see overuse of antibiotics around me all the time. Just the other day my friend's daughter had bronchitis and readily prescribed antibiotics. A couple of days later when it didn't get any better, she got a stronger shot of the same antibiotic. Then it still didn't get any better and another doctor just decided to change it to another kind. There wasn't any of the "let's wait it out and see if this is viral instead of bacterial" or any testing done. And this isn't a single case. It's the norm with 80% of doctors I hear about.
Part of that is viral things often weaken your body enough for a bacterial infection to come in as well. In some (not all) of the most deadly diseases the problem wasn't the initial infection is was secondary.
> ... there's been so many extinction events, yet life still bounced back each time stronger than before.

Nit: The Great Dying, c. 252MYA, took about 10 million years to 'recover' from (though it depended on region, maybe). And the species that came out were not the same that died. As in, they evolved to fill the old niches. The Great Dying was no joke, nearly everything that had more than one cell went poof, like, 96% of all species.

Not to rain on the parade, but we have to work at this. If we do, we are fine, but just posting internet comments is not going to cut it.

Call your congresscritters or other representatives, tell them what you think.

https://en.wikipedia.org/wiki/Permian%E2%80%93Triassic_extin...

> Not to rain on the parade, but we have to work at this. If we do, we are fine, but just posting internet comments is not going to cut it.

I think posting online is a double-edged sword. On the one hand, "clicktivism" and posting hopeful messages soothes that person; on the other hand, if they are that easily soothed, they panic just as easily.

> Call your congresscritters or other representatives, tell them what you think.

This is important. Fortunately I've always lived in a district where my representatives were almost 100% aligned, but even then it is important to double down on the signal to noise. They love to hear positive feedback as well as negative feedback.

I really needed this optimism, thank you.
I'm with you on this. One of the not-so-physical wonders of the world we have is a lot of scientific, capable minds paired with high technology and rapid feedback on their efforts. The timing, though it could have been better, is on our side.

My one concern is once this whole thing is over there will be a long pause followed by a blame game.

There are already conspiracies floating out there being pushed forward by officials in various countries.

I agree. We are going to go through the depths of hell but once we get past it and yes we will get past it that it will see us having resolved this.
What would be really, really nice is if after the crisis passes the world's best institutions and minds continue to get a significant amount of funding to apply those remarkable science and engineering capabilities for the sake of humanity.

IMHO that is the real issue. We didn't need to be in this crisis in the first place : /.

I can’t find the source I saw the other day, but the CDC ran out of a good chunk of its budget September 2019. Right before all this started.

We, especially the US, keep treating CDC like they’re responsible for fixing diseases after they spread when their focus is prevention. This has been happening repeatedly for at least a couple decades.

Every time, it gets worse because we treat disease as a solved problem.

https://www.theatlantic.com/health/archive/2018/02/cdc-fundi...

Darkest indeed, if you are more than 70 years or have other illnesses then you take every precaution not to get infected.

The rest of the population pray that the Corona quarantine will be scaled back as soon as possible, so we don't have a financial ruin to deal with the next decade or more.

I share your sentiment, this will be amazing and also a 'working together' time.

But - time - is the issue. It's medical. Stuff takes a long time to develop a test, there are real ethical rules that won't get broken I think even now.

50 years ago, there would be either some brave volunteers who would be willing to get infected or some poor souls somewhere who would be unwittingly infected to see the results. No more of this.

It's possible however the CCP may 'volunteer' some prisoners, or they may allow brave citizen volunteers. I can see that happening. (I can see brave volunteers coming from everywhere, but I don't see governments allowing such a program to go forward).

I dont think thats a problem. At the very least there will be doctors who are infected and there is nothing to prevent them testing the vaccine on themselves.
We need people who do not have the disease to act as guinea pigs for vaccines and other therapies, not just people who already have it.

Also, we need to test drugs and therapies that have excessive, even deadly consequences. Again, dilemma.

This is a huge ethical dilemma.

Up to a generation ago, drug companies would run trials in Africa, away from aggressive regulation.

During the Manhattan project, the US Army would run squads of soldiers right through the aftermath of test nuclear explosions, literally to see 'the effect of radiation'.

Many specialist jobs entailed levels of riks unthinkable today. Remember, this is in an era where cars didn't have seat-belts.

In 2020, things have changed, but it's possible totalitarian regimes will find 'volunteers'.

China has been engaging in harvesting the organs of political prisoners, at scale [1]. If they're willing to put people in prison for their ethnicity, and then 'have them die' so that a rich person can get a kidney through back channels ... then absolutely they can do medical trials on these people, it may not even need to be publicized.

[1] https://www.nationalreview.com/corner/china-credibly-accused...

I love that the 'tribunal' starts its conclusion with 'If the accusations are true'.

They can be true, but remember the Curveball dossier that helped to start a war.

In a February 2011 interview with The Guardian he [Rafid al-Janabi] "admitted for the first time that he lied about his story, then watched in shock as it was used to justify the war."

https://en.m.wikipedia.org/wiki/Curveball_(informant)

I'm aware of all that stuff, I was just saying there is no ethical dillema or procedure if you want to do medical tests on yourself. That's how Barry Marshall proved that Helicobacter pylori causes stomach ulcers.
Imagine if one day we find that a comet is headed directly to us. That would test and push humanity at its extremes.
How certain would the experts have to be to get such coordinated action?

With close approaches, it seems (as a layman) that there are always pretty large ranges of just how close they will be. I dont think you'd know "a comet is headed directly at us" until way too late. Instead you'd get some warning that there is a 10% chance or something. Over time that would go up to a near certainty. Maybe I'm pessimistic, but I would predict something more similar to climate change with deniers and paralysis.

This remark reminds me of the book, "Seveneves" by Neal Stephenson. He plays with a similar 'what if?' doomsday scenario. Around 80% of the book revolves around testing and pushing humanity at it's extremes.
> we're going to see the world's best institutions and minds working on vaccines and treatments with essentially unlimited funding and top priority.

Trump was caught out trying to buy a CureVac, who are working on a vaccine, to corner the market and make it only available to America https://www.washingtonpost.com/world/europe/germany-coronavi...

Will we see a vaccine? Maybe. At pumped up costs? Most definitely

I think it's worth noting that the corporation is trying to do the right thing, even as pushed by the US government to act unethically. Don't always expect that corporations are evil, or that governments will protect us from that.
The problem is the virus will already have done it's damage by the time the vaccine comes out. Mayhaps it will be useful for the next pandemic that comes out of Wuhan's wet markets.
> ... for the sake of humanity.

Considering the actions of the US government in Germany, and most probably the actions of other governments, I'd say for the sake of national interests, not humanity.

I'd be happy to be proven wrong, though: When a vaccine is found I'm sure the government/company behind it will make available to the world for free...

Actions of governments != actions of the people
Governments and corporations are in control of this, not individuals.
Inside of governments and corporations are individuals making all of those decisions. There is a buck and it stops with an individual on a decision, or a couple of individuals at most.

That's how a national emergency gets declared. The President decides to go forward with it. If California declares a state of emergency, it's the governor that has the final say:

https://www.gov.ca.gov/2020/03/04/governor-newsom-declares-s...

And we're back to my first comment...
> When a vaccine is found I'm sure the government/company behind it will make available to the world for free.

I am pretty sure the U.S. government (or actually Trump) will not do that. He will make the world pay dearly for that.

That news about him trying to buy exclusive from the German company was false news and even the company itself put out a statement that it’s false and it never happened. Media very conveniently didn’t report the correction.
That's not Trump-only propensity. German government has confiscated all 3M masks from 3M European distribution center (obviously they didn't literally confiscated them, they just said that they are the only one who can buy them), they didn't care that, say, Italy needs them more.

But I don't blame Germany at all, there came a time where people can see what is important and if economy of their country is healthy - it produces everything people need and if it really make sense to outsource all production elsewhere just to save a few bucks and if the government they elected is able to handle situation.

Ya, I agree but it doesn’t seem sane or advantageous at all.