[bionhoward]

I’m not a doctor, but fusing a complement activator to a natural enzyme and megadosing it is a horrible idea because it’s gonna trigger complement activation in the context of a self protein, which could cause major autoimmunity, and ACE2 overload is gonna overactivate the angiotensin-aldosterone axis and deactivate renin via negative feedback, screw up your electrolytes which could cause arrhythmias, and give you high blood pressure.

To avoid side effects, a therapy ought to be as orthogonal as possible to natural systems. A high dose of a hormone activator smushed together with an immune activator is definitely not orthogonal to natural systems.

More useful to focus on genomic smart bombs like CRISPR Cas13 ( cough, https://github.com/bionicles/coronavirus ) or RNAi because they’re way, way, way, less likely to have side effects, they can last forever, can easily be retargeted to future germs hella quick, etc etc