[organsnyder]

Life isn't like a movie. Anyone who has the knowledge (of the vehicle and its surveillance systems, the schedule, the cargo onboard...) and the capability (skills and resources) to pull off what you're suggesting has plenty of lucrative legal opportunities. And any cargo load valuable enough to make a Hollywood-style heist actually worthwhile would be transported by more secure means.

[zp33]

It doesn't take that much skill to know that a certain stretch of road doesn't have cell signal and how to set fire to a truck. It takes even less skill when you know there's no human on the truck to stop you

[TeMPOraL]

It may or may not work, but I have no doubt that someone will try.