| the physiological cascade that occurs due to disruption of a homeostatic feedback system is the most probable cause of direct lethality. The setpoint and the relative concentrations of the elements in these systems are genetically dictated functions. There is probably some correlate between predisposition to morbidity/mortality and how far ones setpoints deviate from population setpoints. there are 2 prongs to this attack, one is the disruption of angiotensin based signalling and effectation the other is the viral entry to the cell. the virus must do a dance on the head of a pin in a sense to replicate but not hijack somuch of the cells basic metabolism that apoptosis occurs. a virus that allows its host cell to remain viable wins the lottery for natural selection. the problem is that the virus occupies the expression machinery that creates ACE2, in an indiscriminant fashion many other protiens as well. so this means the virus has caused damage by entry the entry damage causes errent feedback which causes further physiological perturberance a secondary round of disruption occurs when ACE2 expression is inhibited thus interfereing with replenishment of ACE2 that has been damaged as well as disrupting the regular recycling of ACE2 and for that matter disrupts expression of the ATI and ATII receptors ---I am not a founder or funder but simply a concerned professional |