This is very clever. But function overloading is something out of static language territory. It feels un-Pythonic and needlessly complicated. Especially when compared to args and *kwargs.
It feels pythonic to me. One thing that I think brings perspective here is the PEP on singledispatch, which is essentially on function overloading, and is implemented in functools!
It removes the construction of multiple branches within your args/kwargs built function to handle this or that if this or that parameter is this type. I think it clarifies otherwise difficult to write functions or functions whose results have more in common then the actual functional internals.
https://www.python.org/dev/peps/pep-0443/