[opencl]

System76 added a 'HiDPI daemon' for handling mixed-DPI multimonitor setups in GNOME to their PopOS distro, in my experience it works less badly than the alternatives.

https://blog.system76.com/post/168340008923/hidpi-is-release...

[nonbirithm]

It's open source also, so you could theoretically use it in a different distro.

https://github.com/pop-os/hidpi-daemon