Yes, this. I have early-stage cateracs, which by-and-latge is not an issue on my 40 inch monitor. But it does mean that my astigmatism drifts around monthly. My prescription changes faster than I can get new lenses cut. The BIGGEST ergonomic issue for my with Python is single versus double quotes. Double quotes are the difference between happily coding all day versus a headache at lunch time and 5% less done. Fuck Black.
Can you say more about how single quotes vs double quotes is helpful for you? I rarely write python, but I have a passion for accessibility and I'm curious about this.