[weare138]

Based on the studies I've read kavalactones, the group of related psychoactive compounds in kava, indirectly activates the GABA-A receptors without directly binding to the benzodiazepine receptors. So it produces the same effect as a mild benzodiazepine, similar to Xanax. But the exact mechanism is still unknown, so there's definitely a risk of interactions with medications, especially benzodiazepines or medication or supplements that interact with the GABA receptors. Plus one of the kavalactones, yangonin, binds to the cannabinoid receptors. It's a selective agonist of the CB1 cannabinoid receptors and a full agonist of the CB2 receptors.