[hirenj]

This looks like a whole lot of rubbish to me. They're excited they managed to get blast hits for these short inserts.

But in the spirit of open-mindedness, what do I need to be convinced this is even interesting? First I want to see where on gp120 these inserts align to. Are they receptor/carbohydrate binding regions? Where do they map to on the coronavirus? These structures are known, so I don't know why this isn't in this manuscript.

If somehow this is engineered, I am honestly impressed that someone could take features from one protein and estimate how to engineer those same features in another protein altogether, with little homology. It's like engineering a monkey tail onto an elephant and somehow getting the elephant to swing through the trees.

[fapjacks]

I appreciate your skepticism (and your sense of humor) but for the benefit of other readers, it is not like engineering a monkey tail onto an elephant and expecting the elephant to swing through the trees.