[reasonattlm]

One of those hidden powers is the destruction of the aging brain. Senescence of glial cells appears to be quite important in the progression of neurodegeneration, as both a source of neuroinflammation and all of its woes, and a mechanism capable of more directly causing neuron death.

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline - https://doi.org/10.1038/s41586-018-0543-y

Tau protein aggregation is associated with cellular senescence in the brain - https://doi.org/10.1111/acel.12840

Flushing out 'zombie cells' could help stave off Parkinson's, study suggests - https://www.theguardian.com/science/2018/jan/23/flushing-out...

Astrocyte senescence: Evidence and significance - https://doi.org/10.1111/acel.12937

The good news here is that the senolytic drug dasatinib crosses the blood-brain barrier and has been demonstrated to destroy senescent glial cells in animal models, and destroy senescent cells elsewhere in the body in human trials. The cheap dasatinib / quercetin combination should be trialed in Alzheimer's and Parkinson's patients, and the sooner the better.