[RL_Quine]

A GPU is an ASIC, which can mine RandomX. The idea that you could make something that's able to only be computed by a general purpose GPU, and not something more specialized, is just absurd. Even if that's just removing the unnecessary display hardware from the GPU and whatever parts of the shaders aren't being used, you still have an advantage.

[Forbo]

GPUs actually have a significant disadvantage on RandomX. Their hashrate is much lower than what you'd get from a CPU.

Edit for more info:

https://monerobenchmarks.info/

According to this site, an overclocked Titan RTX gets about the same hash rate as a stock AMD FX8370E at nearly half the TDP.

[RL_Quine]

Replace GPU with CPU in my answer. It applies to all of the algorithms in one way or another. ASIC resistant is an oxymoron.

[Arnavion]

ASIC-resistant specifically applies when you're talking about using ASICs as ASICs. If you're using ASICs to emulate CPUs (soft microprocessors), that is usually much less efficient than what the ASIC is capable of.